A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila

An “invariant proline” separates the myosin S1 head from its S2 tail and is proposed to be critical for orienting S1 during its interaction with actin, a process that leads to muscle contraction. Mutation of the invariant proline to leucine (P838L) caused dominant restrictive cardiomyopathy in a ped...

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Veröffentlicht in:J Mol Biol
Hauptverfasser: Achal, Madhulika, Trujillo, Adriana S., Melkani, Girish C., Farman, Gerrie P., Ocorr, Karen, Viswanathan, Meera C., Kaushik, Gaurav, Newhard, Christopher S., Glasheen, Bernadette M., Melkani, Anju, Suggs, Jennifer A., Moore, Jeffrey R., Swank, Douglas M., Bodmer, Rolf, Cammarato, Anthony, Bernstein, Sanford I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884507/
https://ncbi.nlm.nih.gov/pubmed/27107639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.04.021
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