Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy

K146N is a dominant mutation in human β-cardiac myosin heavy chain, which causes hypertrophic cardiomyopathy. We examined how Drosophila muscle responds to this mutation and integratively analyzed the biochemical, physiological and mechanical foundations of the disease. ATPase assays, actin motility...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kronert, William A, Bell, Kaylyn M, Viswanathan, Meera C, Melkani, Girish C, Trujillo, Adriana S, Huang, Alice, Melkani, Anju, Cammarato, Anthony, Swank, Douglas M, Bernstein, Sanford I
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141233/
https://ncbi.nlm.nih.gov/pubmed/30102150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38064
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados