Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy

K146N is a dominant mutation in human β-cardiac myosin heavy chain, which causes hypertrophic cardiomyopathy. We examined how Drosophila muscle responds to this mutation and integratively analyzed the biochemical, physiological and mechanical foundations of the disease. ATPase assays, actin motility...

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Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Kronert, William A, Bell, Kaylyn M, Viswanathan, Meera C, Melkani, Girish C, Trujillo, Adriana S, Huang, Alice, Melkani, Anju, Cammarato, Anthony, Swank, Douglas M, Bernstein, Sanford I
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2018
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141233/
https://ncbi.nlm.nih.gov/pubmed/30102150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38064
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