The R249Q hypertrophic cardiomyopathy myosin mutation decreases contractility in Drosophila by impeding force production

KEY POINTS: Hypertrophic cardiomyopathy (HCM) is a genetic disease that causes thickening of the heart's ventricular walls and is a leading cause of sudden cardiac death. HCM is caused by missense mutations in muscle proteins including myosin, but how these mutations alter muscle mechanical per...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Physiol
Main Authors: Bell, Kaylyn M., Kronert, William A., Huang, Alice, Bernstein, Sanford I., Swank, Douglas M.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2019
Assuntos:
Muscle
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487941/
https://ncbi.nlm.nih.gov/pubmed/30950055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP277333
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares