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The R249Q hypertrophic cardiomyopathy myosin mutation decreases contractility in Drosophila by impeding force production
KEY POINTS: Hypertrophic cardiomyopathy (HCM) is a genetic disease that causes thickening of the heart's ventricular walls and is a leading cause of sudden cardiac death. HCM is caused by missense mutations in muscle proteins including myosin, but how these mutations alter muscle mechanical per...
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| Publicado no: | J Physiol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6487941/ https://ncbi.nlm.nih.gov/pubmed/30950055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP277333 |
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