The R249Q hypertrophic cardiomyopathy myosin mutation decreases contractility in Drosophila by impeding force production

KEY POINTS: Hypertrophic cardiomyopathy (HCM) is a genetic disease that causes thickening of the heart's ventricular walls and is a leading cause of sudden cardiac death. HCM is caused by missense mutations in muscle proteins including myosin, but how these mutations alter muscle mechanical per...

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Detalles Bibliográficos
Publicado en:J Physiol
Autores principales: Bell, Kaylyn M., Kronert, William A., Huang, Alice, Bernstein, Sanford I., Swank, Douglas M.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
Materias:
Muscle
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487941/
https://ncbi.nlm.nih.gov/pubmed/30950055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP277333
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