Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy

K146N is a dominant mutation in human β-cardiac myosin heavy chain, which causes hypertrophic cardiomyopathy. We examined how Drosophila muscle responds to this mutation and integratively analyzed the biochemical, physiological and mechanical foundations of the disease. ATPase assays, actin motility...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Kronert, William A, Bell, Kaylyn M, Viswanathan, Meera C, Melkani, Girish C, Trujillo, Adriana S, Huang, Alice, Melkani, Anju, Cammarato, Anthony, Swank, Douglas M, Bernstein, Sanford I
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2018
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141233/
https://ncbi.nlm.nih.gov/pubmed/30102150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38064
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