Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy

K146N is a dominant mutation in human β-cardiac myosin heavy chain, which causes hypertrophic cardiomyopathy. We examined how Drosophila muscle responds to this mutation and integratively analyzed the biochemical, physiological and mechanical foundations of the disease. ATPase assays, actin motility...

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Publicado en:eLife
Autores principales: Kronert, William A, Bell, Kaylyn M, Viswanathan, Meera C, Melkani, Girish C, Trujillo, Adriana S, Huang, Alice, Melkani, Anju, Cammarato, Anthony, Swank, Douglas M, Bernstein, Sanford I
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141233/
https://ncbi.nlm.nih.gov/pubmed/30102150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38064
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