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Huntington's Disease Induced Cardiac Amyloidosis Is Reversed by Modulating Protein Folding and Oxidative Stress Pathways in the Drosophila Heart

Amyloid-like inclusions have been associated with Huntington's disease (HD), which is caused by expanded polyglutamine repeats in the Huntingtin protein. HD patients exhibit a high incidence of cardiovascular events, presumably as a result of accumulation of toxic amyloid-like inclusions. We ha...

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Bibliografiske detaljer
Main Authors: Melkani, Girish C., Trujillo, Adriana S., Ramos, Raul, Bodmer, Rolf, Bernstein, Sanford I., Ocorr, Karen
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868535/
https://ncbi.nlm.nih.gov/pubmed/24367279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004024
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