Combination Pod-Intravaginal Ring Delivers Antiretroviral Agents for HIV Prophylaxis: Pharmacokinetic Evaluation in an Ovine Model

Preexposure prophylaxis (PrEP) against HIV using oral regimens based on the nucleoside reverse transcriptase inhibitor tenofovir disoproxil fumarate (TDF) has been effective to various degrees in multiple clinical trials, and the CCR5 receptor antagonist maraviroc (MVC) holds potential for complemen...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Moss, John A., Butkyavichene, Irina, Churchman, Scott A., Gunawardana, Manjula, Fanter, Rob, Miller, Christine S., Yang, Flora, Easley, Jeremiah T., Marzinke, Mark A., Hendrix, Craig W., Smith, Thomas J., Baum, Marc M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879417/
https://ncbi.nlm.nih.gov/pubmed/27067321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00391-16
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