Safety and pharmacokinetics of single, dual, and triple antiretroviral drug formulations delivered by pod-intravaginal rings designed for HIV-1 prevention: A Phase I trial

BACKGROUND: Intravaginal rings (IVRs) for HIV pre-exposure prophylaxis (PrEP) theoretically overcome some adherence concerns associated with frequent dosing that can occur with oral or vaginal film/gel regimens. An innovative pod-IVR, composed of an elastomer scaffold that can hold up to 10 polymer-...

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Detalhes bibliográficos
Publicado no:PLoS Med
Main Authors: Vincent, Kathleen L., Moss, John A., Marzinke, Mark A., Hendrix, Craig W., Anton, Peter A., Pyles, Richard B., Guthrie, Kate M., Dawson, Lauren, Olive, Trevelyn J., Butkyavichene, Irina, Churchman, Scott A., Cortez, John M., Fanter, Rob, Gunawardana, Manjula, Miller, Christine S., Yang, Flora, Rosen, Rochelle K., Vargas, Sara E., Baum, Marc M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161852/
https://ncbi.nlm.nih.gov/pubmed/30265679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002655
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