Safety and pharmacokinetics of single, dual, and triple antiretroviral drug formulations delivered by pod-intravaginal rings designed for HIV-1 prevention: A Phase I trial

BACKGROUND: Intravaginal rings (IVRs) for HIV pre-exposure prophylaxis (PrEP) theoretically overcome some adherence concerns associated with frequent dosing that can occur with oral or vaginal film/gel regimens. An innovative pod-IVR, composed of an elastomer scaffold that can hold up to 10 polymer-...

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Bibliografski detalji
Izdano u:PLoS Med
Glavni autori: Vincent, Kathleen L., Moss, John A., Marzinke, Mark A., Hendrix, Craig W., Anton, Peter A., Pyles, Richard B., Guthrie, Kate M., Dawson, Lauren, Olive, Trevelyn J., Butkyavichene, Irina, Churchman, Scott A., Cortez, John M., Fanter, Rob, Gunawardana, Manjula, Miller, Christine S., Yang, Flora, Rosen, Rochelle K., Vargas, Sara E., Baum, Marc M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2018
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161852/
https://ncbi.nlm.nih.gov/pubmed/30265679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002655
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