Pharmacokinetics and Preliminary Safety Study of Pod-Intravaginal Rings Delivering Antiretroviral Combinations for HIV Prophylaxis in a Macaque Model

Preexposure prophylaxis using oral regimens involving the HIV nucleoside reverse transcriptase inhibitors tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) demonstrated efficacy in three clinical trials. Adherence was determined to be a key parameter for success. Incorporation of the TDF-F...

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Main Authors: Moss, John A., Srinivasan, Priya, Smith, Thomas J., Butkyavichene, Irina, Lopez, Gilbert, Brooks, Amanda A., Martin, Amy, Dinh, Chuong T., Smith, James M., Baum, Marc M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135875/
https://ncbi.nlm.nih.gov/pubmed/24936594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02871-14
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