Topical Delivery of Tenofovir Disoproxil Fumarate and Emtricitabine from Pod-Intravaginal Rings Protects Macaques from Multiple SHIV Exposures

Topical preexposure prophylaxis (PrEP) against HIV has been marginally successful in recent clinical trials with low adherence rates being a primary factor for failure. Controlled, sustained release of antiretroviral (ARV) drugs may help overcome these low adherence rates if the product is protectiv...

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Veröffentlicht in:PLoS One
Hauptverfasser: Srinivasan, Priya, Moss, John A., Gunawardana, Manjula, Churchman, Scott A., Yang, Flora, Dinh, Chuong T., Mitchell, James M., Zhang, Jining, Fanter, Rob, Miller, Christine S., Butkyavichene, Irina, McNicholl, Janet M., Smith, Thomas J., Baum, Marc M., Smith, James M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4898685/
https://ncbi.nlm.nih.gov/pubmed/27275923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157061
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