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Peptidoglycan Modifications Tune the Stability and Function of the Innate Immune Receptor Nod2

Natural modifications of peptidoglycan modulate the innate immune response. Peptidoglycan derivatives activate this response via the intracellular innate immune receptor, Nod2. To probe how these modifications alter the response, a novel and eficient carbohydrate synthesis was developed to allow for...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Melnyk, James E., Mohanan, Vishnu, Schaefer, Amy K., Hou, Ching-Wen, Grimes, Catherine Leimkuhler
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878121/
https://ncbi.nlm.nih.gov/pubmed/26035228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b01607
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