Llwytho...
Crohn’s disease variants of Nod2 are stabilized by critical contact region of Hsp70
Nod2 is a cytosolic, innate immune receptor responsible for binding to bacterial cell wall fragments such as muramyl dipeptide (MDP). Upon binding, subsequent downstream activation of the NF-κB pathway leads to an immune response. Nod2 mutations are correlated with an increased susceptibility for Cr...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Biochemistry |
|---|---|
| Prif Awduron: | , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2017
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5820029/ https://ncbi.nlm.nih.gov/pubmed/28792733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00470 |
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