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Bromopyridone Nucleotide Analogues, Anoxic Selective Radiosensitizing Agents That Are Incorporated in DNA by Polymerases

Ionizing radiation is frequently used to kill tumor cells. However, hypoxic solid tumor cells are more resistant to this treatment, providing the impetus to develop molecules that sensitize cells to ionizing radiation. 5-Bromo-2′-deoxyuridine (BrdU) has been investigated as a radiosensitizing agent...

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Podrobná bibliografie
Vydáno v:J Org Chem
Hlavní autoři: Rudra, Arnab, Hou, Dianjie, Zhang, Yonggang, Coulter, Jonathan, Zhou, Haoming, DeWeese, Theodore L., Greenberg, Marc M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877698/
https://ncbi.nlm.nih.gov/pubmed/26509218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.5b01833
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