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Bromopyridone Nucleotide Analogues, Anoxic Selective Radiosensitizing Agents That Are Incorporated in DNA by Polymerases

Ionizing radiation is frequently used to kill tumor cells. However, hypoxic solid tumor cells are more resistant to this treatment, providing the impetus to develop molecules that sensitize cells to ionizing radiation. 5-Bromo-2′-deoxyuridine (BrdU) has been investigated as a radiosensitizing agent...

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Bibliografiske detaljer
Udgivet i:J Org Chem
Main Authors: Rudra, Arnab, Hou, Dianjie, Zhang, Yonggang, Coulter, Jonathan, Zhou, Haoming, DeWeese, Theodore L., Greenberg, Marc M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877698/
https://ncbi.nlm.nih.gov/pubmed/26509218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.5b01833
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