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Irreversible Inhibition of DNA Polymerase β by Small Molecule Mimics of a DNA Lesion
Abasic sites are ubiquitous DNA lesions that are mutagenic and cytotoxic but are removed by the base excision repair pathway. DNA polymerase β carries out two of the four steps during base excision repair, including a lyase reaction that removes the abasic site from DNA following incision of its 5′-...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4047187/ https://ncbi.nlm.nih.gov/pubmed/24517090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja411733s |
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