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Synergistic Effects of an Irreversible DNA Polymerase Inhibitor and DNA Damaging Agents on HeLa Cells

DNA repair is vital to maintaining genome integrity, but thwarts the effects of cytotoxic agents that target nucleic acids. Consequently, repair enzymes are potential targets for molecules that modulate cell function and anti-cancer therapeutics. DNA polymerase β (Pol β) is an attractive target beca...

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Foilsithe in:ACS Chem Biol
Main Authors: Paul, Rakesh, Banerjee, Samya, Greenberg, Marc M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5492961/
https://ncbi.nlm.nih.gov/pubmed/28459532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00259
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