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Synergistic Effects of an Irreversible DNA Polymerase Inhibitor and DNA Damaging Agents on HeLa Cells

DNA repair is vital to maintaining genome integrity, but thwarts the effects of cytotoxic agents that target nucleic acids. Consequently, repair enzymes are potential targets for molecules that modulate cell function and anti-cancer therapeutics. DNA polymerase β (Pol β) is an attractive target beca...

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Pubblicato in:ACS Chem Biol
Autori principali: Paul, Rakesh, Banerjee, Samya, Greenberg, Marc M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5492961/
https://ncbi.nlm.nih.gov/pubmed/28459532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00259
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