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Butylanilinouracil: a selective inhibitor of HeLa cell DNA synthesis and HeLa cell DNA polymerase alpha.

A series of 6-anilinouracils, dGTP analogues which selectively inhibit specific bacterial DNA polymerases, were examined for their capacity to inhibit purified DNA polymerases from HeLa cells. The p-n-butyl derivative (BuAU) was found to inhibit DNA polymerase alpha with a Ki of approximately 60 mic...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Wright, G E, Baril, E F, Brown, N C
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1980
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327245/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6153466/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/8.1.99
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