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Structure-activity relationships for the inhibition of DNA polymerase alpha by aphidicolin derivatives.
Aphidicolin and 17 derivatives that have been structurally modified in the A- and D-rings were assessed for their ability to inhibit DNA polymerase alpha. No derivative surpassed the activity of aphidicolin; derivatives with structural alterations in the A-ring exhibited significantly greater loss o...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
1989
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| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC318281/ https://ncbi.nlm.nih.gov/pubmed/2505232 |
| タグ: |
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