Structure-activity relationships for the inhibition of DNA polymerase alpha by aphidicolin derivatives.
Aphidicolin and 17 derivatives that have been structurally modified in the A- and D-rings were assessed for their ability to inhibit DNA polymerase alpha. No derivative surpassed the activity of aphidicolin; derivatives with structural alterations in the A-ring exhibited significantly greater loss o...
Guardat en:
| Publicat a: | Nucleic Acids Res |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
1989
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| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC318281/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2505232/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/17.15.6339 |
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