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Structure-activity relationships for the inhibition of DNA polymerase alpha by aphidicolin derivatives.

Aphidicolin and 17 derivatives that have been structurally modified in the A- and D-rings were assessed for their ability to inhibit DNA polymerase alpha. No derivative surpassed the activity of aphidicolin; derivatives with structural alterations in the A-ring exhibited significantly greater loss o...

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Bibliografiske detaljer
Main Authors: Prasad, G, Edelson, R A, Gorycki, P D, Macdonald, T L
Format: Artigo
Sprog:Inglês
Udgivet: 1989
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC318281/
https://ncbi.nlm.nih.gov/pubmed/2505232
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