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Bromopyridone Nucleotide Analogues, Anoxic Selective Radiosensitizing Agents That Are Incorporated in DNA by Polymerases
Ionizing radiation is frequently used to kill tumor cells. However, hypoxic solid tumor cells are more resistant to this treatment, providing the impetus to develop molecules that sensitize cells to ionizing radiation. 5-Bromo-2′-deoxyuridine (BrdU) has been investigated as a radiosensitizing agent...
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| Publicado no: | J Org Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4877698/ https://ncbi.nlm.nih.gov/pubmed/26509218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.5b01833 |
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