Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β

Progranulin (PGRN) has recently emerged as a key player in a subset of frontotemporal dementias (FTD). Numerous mutations in the progranulin gene have been identified in patients with familial or sporadic frontotemporal lobar degeneration (FTLD). In order to understand the molecular mechanisms by wh...

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Veröffentlicht in:Protein Cell
Hauptverfasser: Gao, Xue, Joselin, Alvin P., Wang, Lei, Kar, Amar, Ray, Payal, Bateman, Andrew, Goate, Alison M., Wu, Jane Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Higher Education Press 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875315/
https://ncbi.nlm.nih.gov/pubmed/21204008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-010-0067-1
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