Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

Recently, mutations in the progranulin (PGRN) gene were found to cause familial and apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in PGRN were identified in patients with motor neuron degeneration, a condition that is related to FTLD. Most mutations identified i...

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Detalhes bibliográficos
Main Authors: Van Damme, Philip, Van Hoecke, Annelies, Lambrechts, Diether, Vanacker, Peter, Bogaert, Elke, van Swieten, John, Carmeliet, Peter, Van Den Bosch, Ludo, Robberecht, Wim
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2287280/
https://ncbi.nlm.nih.gov/pubmed/18378771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200712039
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