Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

Recently, mutations in the progranulin (PGRN) gene were found to cause familial and apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in PGRN were identified in patients with motor neuron degeneration, a condition that is related to FTLD. Most mutations identified i...

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Bibliographische Detailangaben
Hauptverfasser: Van Damme, Philip, Van Hoecke, Annelies, Lambrechts, Diether, Vanacker, Peter, Bogaert, Elke, van Swieten, John, Carmeliet, Peter, Van Den Bosch, Ludo, Robberecht, Wim
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2008
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2287280/
https://ncbi.nlm.nih.gov/pubmed/18378771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200712039
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