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Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo
Loss of function mutations in progranulin (GRN) cause frontotemporal dementia, but how GRN haploinsufficiency causes neuronal dysfunction remains unclear. We previously showed that GRN is neurotrophic in vitro. Here, we used an in vivo axonal outgrowth system and observed a delayed recovery in GRN(−...
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| Publicat a: | Hum Mol Genet |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5886064/ https://ncbi.nlm.nih.gov/pubmed/28453791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx162 |
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