Progranulin is Neurotrophic In Vivo and Protects against a Mutant TDP-43 Induced Axonopathy

Mislocalization, aberrant processing and aggregation of TAR DNA-binding protein 43 (TDP-43) is found in the neurons affected by two related diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal lobe dementia (FTLD). These TDP-43 abnormalities are seen when TDP-43 is mutated, such as in fa...

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Главные авторы: Laird, Angela S., Van Hoecke, Annelies, De Muynck, Louis, Timmers, Mieke, Van Den Bosch, Ludo, Van Damme, Philip, Robberecht, Wim
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2010
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954192/
https://ncbi.nlm.nih.gov/pubmed/20967127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013368
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