Progranulin is Neurotrophic In Vivo and Protects against a Mutant TDP-43 Induced Axonopathy

Mislocalization, aberrant processing and aggregation of TAR DNA-binding protein 43 (TDP-43) is found in the neurons affected by two related diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal lobe dementia (FTLD). These TDP-43 abnormalities are seen when TDP-43 is mutated, such as in fa...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Laird, Angela S., Van Hoecke, Annelies, De Muynck, Louis, Timmers, Mieke, Van Den Bosch, Ludo, Van Damme, Philip, Robberecht, Wim
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2010
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954192/
https://ncbi.nlm.nih.gov/pubmed/20967127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013368
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares