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Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice
BACKGROUND: Intraneuronal inclusions of TAR DNA-binding protein 43 (TDP-43) have been found in the majority of Amyotrophic Lateral Sclerosis (ALS) patients. Mutations in the gene encoding TDP-43 cause familial ALS. Transgenic mice expressing mutant TDP-43 with one such mutation (TDP-43 (A315T)) unde...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4088917/ https://ncbi.nlm.nih.gov/pubmed/24938805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-24 |
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