Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice

BACKGROUND: Intraneuronal inclusions of TAR DNA-binding protein 43 (TDP-43) have been found in the majority of Amyotrophic Lateral Sclerosis (ALS) patients. Mutations in the gene encoding TDP-43 cause familial ALS. Transgenic mice expressing mutant TDP-43 with one such mutation (TDP-43 (A315T)) unde...

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Main Authors: Herdewyn, Sarah, Cirillo, Carla, Van Den Bosch, Ludo, Robberecht, Wim, Vanden Berghe, Pieter, Van Damme, Philip
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4088917/
https://ncbi.nlm.nih.gov/pubmed/24938805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-24
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