Atorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt/mTOR and Akt/GSK-3β signaling pathways

AIM: To investigate whether atorvastatin can promote formation of neurites in cultured cortical neurons and the signaling mechanisms responsible for this effect. METHODS: Cultured rat cerebral cortical neurons were incubated with atorvastatin (0.05–10 μmol/L) for various lengths of time. For pharmac...

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Autores principales: Jin, Ying, Sui, Hai-juan, Dong, Yan, Ding, Qi, Qu, Wen-hui, Yu, Sheng-xue, Jin, Ying-xin
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011150/
https://ncbi.nlm.nih.gov/pubmed/22705730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.59
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