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Cortical deficiency of laminin γ1 impairs the AKT/GSK-3β signaling pathway and leads to defects in neurite outgrowth and neuronal migration

Laminins have dramatic and varied actions on neurons in vitro. However, their in vivo function in brain development is not clear. Here we show that knockout of laminin γ1 in the cerebral cortex leads to defects in neuritogenesis and neuronal migration. In the mutant mice, cortical layer structures w...

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Detalhes bibliográficos
Main Authors: Chen, Zu-Lin, Haegeli, Véronique, Yu, Huaxu, Strickland, Sidney
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669444/
https://ncbi.nlm.nih.gov/pubmed/19118544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2008.12.006
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