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Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β

Progranulin (PGRN) has recently emerged as a key player in a subset of frontotemporal dementias (FTD). Numerous mutations in the progranulin gene have been identified in patients with familial or sporadic frontotemporal lobar degeneration (FTLD). In order to understand the molecular mechanisms by wh...

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Detalhes bibliográficos
Publicado no:Protein Cell
Main Authors: Gao, Xue, Joselin, Alvin P., Wang, Lei, Kar, Amar, Ray, Payal, Bateman, Andrew, Goate, Alison M., Wu, Jane Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Higher Education Press 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875315/
https://ncbi.nlm.nih.gov/pubmed/21204008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-010-0067-1
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