Mechanical slowing-down of cytoplasmic diffusion allows in vivo counting of proteins in individual cells

Many key regulatory proteins in bacteria are present in too low numbers to be detected with conventional methods, which poses a particular challenge for single-cell analyses because such proteins can contribute greatly to phenotypic heterogeneity. Here we develop a microfluidics-based platform that...

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Pubblicato in:Nat Commun
Autori principali: Okumus, Burak, Landgraf, Dirk, Lai, Ghee Chuan, Bakhsi, Somenath, Arias-Castro, Juan Carlos, Yildiz, Sadik, Huh, Dann, Fernandez-Lopez, Raul, Peterson, Celeste N., Toprak, Erdal, El Karoui, Meriem, Paulsson, Johan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873973/
https://ncbi.nlm.nih.gov/pubmed/27189321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11641
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Accesso online

https://ncbi.nlm.nih.gov/pmc/articles/PMC4873973/
https://ncbi.nlm.nih.gov/pubmed/27189321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11641

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