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Mechanical slowing-down of cytoplasmic diffusion allows in vivo counting of proteins in individual cells

Many key regulatory proteins in bacteria are present in too low numbers to be detected with conventional methods, which poses a particular challenge for single-cell analyses because such proteins can contribute greatly to phenotypic heterogeneity. Here we develop a microfluidics-based platform that...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nat Commun
Main Authors: Okumus, Burak, Landgraf, Dirk, Lai, Ghee Chuan, Bakhsi, Somenath, Arias-Castro, Juan Carlos, Yildiz, Sadik, Huh, Dann, Fernandez-Lopez, Raul, Peterson, Celeste N., Toprak, Erdal, El Karoui, Meriem, Paulsson, Johan
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873973/
https://ncbi.nlm.nih.gov/pubmed/27189321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11641
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