Mechanical slowing-down of cytoplasmic diffusion allows in vivo counting of proteins in individual cells

Many key regulatory proteins in bacteria are present in too low numbers to be detected with conventional methods, which poses a particular challenge for single-cell analyses because such proteins can contribute greatly to phenotypic heterogeneity. Here we develop a microfluidics-based platform that...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Okumus, Burak, Landgraf, Dirk, Lai, Ghee Chuan, Bakhsi, Somenath, Arias-Castro, Juan Carlos, Yildiz, Sadik, Huh, Dann, Fernandez-Lopez, Raul, Peterson, Celeste N., Toprak, Erdal, El Karoui, Meriem, Paulsson, Johan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873973/
https://ncbi.nlm.nih.gov/pubmed/27189321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11641
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