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Mechanical slowing-down of cytoplasmic diffusion allows in vivo counting of proteins in individual cells
Many key regulatory proteins in bacteria are present in too low numbers to be detected with conventional methods, which poses a particular challenge for single-cell analyses because such proteins can contribute greatly to phenotypic heterogeneity. Here we develop a microfluidics-based platform that...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4873973/ https://ncbi.nlm.nih.gov/pubmed/27189321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11641 |
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