TGFβ signaling in the pancreatic tumor microenvironment promotes fibrosis and immune evasion to facilitate tumorigenesis

In early pancreatic carcinogenesis, TGFβ acts as a tumor suppressor due to its growth-inhibitory effects in epithelial cells. However, in advanced disease, TGFβ appears to promote tumor progression. Therefore, to better understand the contributions of TGFβ signaling to pancreatic carcinogenesis, we...

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Опубликовано в: :Cancer Res
Главные авторы: Principe, Daniel R., DeCant, Brian, Mascariñas, Emman, Wayne, Elizabeth A., Diaz, Andrew M., Diaz, Naomi, Hwang, Rosa, Pasche, Boris, Dawson, David W., Fang, Deyu, Bentrem, David J., Munshi, Hidayatullah G., Jung, Barbara, Grippo, Paul J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873388/
https://ncbi.nlm.nih.gov/pubmed/26980767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1293
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