TGFβ signaling in the pancreatic tumor microenvironment promotes fibrosis and immune evasion to facilitate tumorigenesis

In early pancreatic carcinogenesis, TGFβ acts as a tumor suppressor due to its growth-inhibitory effects in epithelial cells. However, in advanced disease, TGFβ appears to promote tumor progression. Therefore, to better understand the contributions of TGFβ signaling to pancreatic carcinogenesis, we...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Principe, Daniel R., DeCant, Brian, Mascariñas, Emman, Wayne, Elizabeth A., Diaz, Andrew M., Diaz, Naomi, Hwang, Rosa, Pasche, Boris, Dawson, David W., Fang, Deyu, Bentrem, David J., Munshi, Hidayatullah G., Jung, Barbara, Grippo, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873388/
https://ncbi.nlm.nih.gov/pubmed/26980767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1293
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