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BET inhibitors block pancreatic stellate cell collagen I production and attenuate fibrosis in vivo
The fibrotic reaction, which can account for over 70%–80% of the tumor mass, is a characteristic feature of human pancreatic ductal adenocarcinoma (PDAC) tumors. It is associated with activation and proliferation of pancreatic stellate cells (PSCs), which are key regulators of collagen I production...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5291732/ https://ncbi.nlm.nih.gov/pubmed/28194432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88032 |
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