BET inhibitors block pancreatic stellate cell collagen I production and attenuate fibrosis in vivo

The fibrotic reaction, which can account for over 70%–80% of the tumor mass, is a characteristic feature of human pancreatic ductal adenocarcinoma (PDAC) tumors. It is associated with activation and proliferation of pancreatic stellate cells (PSCs), which are key regulators of collagen I production...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Kumar, Krishan, DeCant, Brian T., Grippo, Paul J., Hwang, Rosa F., Bentrem, David J., Ebine, Kazumi, Munshi, Hidayatullah G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291732/
https://ncbi.nlm.nih.gov/pubmed/28194432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88032
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