BET bromodomain inhibitors block growth of pancreatic cancer cells in three-dimensional collagen

Pancreatic ductal adenocarcinoma (PDAC) is associated with pronounced fibrosis that contributes to chemoresistance, in part, through increased histone acetylation. Since bromodomain (BRD) and extra terminal domain (BET) proteins are ‘readers’ of histone acetylation marks, we targeted BET proteins in...

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Detalhes bibliográficos
Main Authors: Sahai, Vaibhav, Kumar, Krishan, Knab, Lawrence M., Chow, Christina R., Raza, Sania S., Bentrem, David J., Ebine, Kazumi, Munshi, Hidayatullah G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090266/
https://ncbi.nlm.nih.gov/pubmed/24807963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0925
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