GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1

JQ1 and I-BET151 are selective inhibitors of BET bromodomain proteins that have efficacy against a number of different cancers. Since the effectiveness of targeted therapies is often limited by development of resistance, we examined whether it was possible for cancer cells to develop resistance to t...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kumar, Krishan, Raza, Sania S., Knab, Lawrence M., Chow, Christina R., Kwok, Benjamin, Bentrem, David J., Popovic, Relja, Ebine, Kazumi, Licht, Jonathan D., Munshi, Hidayatullah G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452877/
https://ncbi.nlm.nih.gov/pubmed/25807524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09489
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