TGFβ signaling in the pancreatic tumor microenvironment promotes fibrosis and immune evasion to facilitate tumorigenesis

In early pancreatic carcinogenesis, TGFβ acts as a tumor suppressor due to its growth-inhibitory effects in epithelial cells. However, in advanced disease, TGFβ appears to promote tumor progression. Therefore, to better understand the contributions of TGFβ signaling to pancreatic carcinogenesis, we...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Res
Egile Nagusiak: Principe, Daniel R., DeCant, Brian, Mascariñas, Emman, Wayne, Elizabeth A., Diaz, Andrew M., Diaz, Naomi, Hwang, Rosa, Pasche, Boris, Dawson, David W., Fang, Deyu, Bentrem, David J., Munshi, Hidayatullah G., Jung, Barbara, Grippo, Paul J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873388/
https://ncbi.nlm.nih.gov/pubmed/26980767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1293
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