TGFβ signaling in the pancreatic tumor microenvironment promotes fibrosis and immune evasion to facilitate tumorigenesis

In early pancreatic carcinogenesis, TGFβ acts as a tumor suppressor due to its growth-inhibitory effects in epithelial cells. However, in advanced disease, TGFβ appears to promote tumor progression. Therefore, to better understand the contributions of TGFβ signaling to pancreatic carcinogenesis, we...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cancer Res
Päätekijät: Principe, Daniel R., DeCant, Brian, Mascariñas, Emman, Wayne, Elizabeth A., Diaz, Andrew M., Diaz, Naomi, Hwang, Rosa, Pasche, Boris, Dawson, David W., Fang, Deyu, Bentrem, David J., Munshi, Hidayatullah G., Jung, Barbara, Grippo, Paul J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873388/
https://ncbi.nlm.nih.gov/pubmed/26980767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1293
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