A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

Oncogene activation has been shown to generate replication-born DNA damage, also known as replicative stress (RS). Notably, the ATR kinase –and not ATM- is the primary responder to RS. One limitation for the study of ATR is the lack of potent inhibitors. We here describe a cell-based screening strat...

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Pubblicato in:Nat Struct Mol Biol
Autori principali: Toledo, Luis I., Murga, Matilde, Zur, Rafal, Soria, Rebeca, Rodriguez, Antonio, Martinez, Sonia, Oyarzabal, Julen, Pastor, Joaquin, Bischoff, James R., Fernandez-Capetillo, Oscar
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869831/
https://ncbi.nlm.nih.gov/pubmed/21552262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2076
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