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A genomewide CRISPR screen identifies CDC25A as a determinant of sensitivity to ATR inhibitors
One recurring theme in drug development is to exploit synthetic lethal properties as means to preferentially damage the DNA of cancer cells. Others and we have previously developed inhibitors of the ATR kinase, and shown are particularly genotoxic for cells expressing certain oncogenes. In contrast,...
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| Gepubliceerd in: | Mol Cell |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5029544/ https://ncbi.nlm.nih.gov/pubmed/27067599 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.03.006 |
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