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A genomewide CRISPR screen identifies CDC25A as a determinant of sensitivity to ATR inhibitors

One recurring theme in drug development is to exploit synthetic lethal properties as means to preferentially damage the DNA of cancer cells. Others and we have previously developed inhibitors of the ATR kinase, and shown are particularly genotoxic for cells expressing certain oncogenes. In contrast,...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Ruiz, Sergio, Mayor-Ruiz, Cristina, Lafarga, Vanesa, Murga, Matilde, Vega-Sendino, Maria, Ortega, Sagrario, Fernandez-Capetillo, Oscar
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029544/
https://ncbi.nlm.nih.gov/pubmed/27067599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.03.006
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