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A genomewide CRISPR screen identifies CDC25A as a determinant of sensitivity to ATR inhibitors

One recurring theme in drug development is to exploit synthetic lethal properties as means to preferentially damage the DNA of cancer cells. Others and we have previously developed inhibitors of the ATR kinase, and shown are particularly genotoxic for cells expressing certain oncogenes. In contrast,...

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Publicat a:Mol Cell
Autors principals: Ruiz, Sergio, Mayor-Ruiz, Cristina, Lafarga, Vanesa, Murga, Matilde, Vega-Sendino, Maria, Ortega, Sagrario, Fernandez-Capetillo, Oscar
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029544/
https://ncbi.nlm.nih.gov/pubmed/27067599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.03.006
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