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Targeting ATR and Chk1 kinases for cancer treatment: A new model for new (and old) drugs

Trying to kill cancer cells by generating DNA damage is by no means a new idea. Radiotherapy and genotoxic drugs are routinely used in cancer therapy. More recent developments also explored the potential of targeting the DNA damage response (DDR) in order to increase the toxicity of radio‐ and chemo...

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Detalhes bibliográficos
Main Authors: Toledo, Luis I., Murga, Matilde, Fernandez‐Capetillo, Oscar
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590794/
https://ncbi.nlm.nih.gov/pubmed/21820372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2011.07.002
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