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ATR signaling can drive cells into senescence in the absence of DNA breaks
The ATR kinase is a key transducer of “replicative stress,” the type of genomic damage that has been postulated to be induced by oncogenes. Here we describe a cellular system in which we can unleash ATR activity at will, in the absence of any actual damage or additional signaling pathways triggered...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Cold Spring Harbor Laboratory Press
2008
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2216689/ https://ncbi.nlm.nih.gov/pubmed/18245444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.452308 |
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