ATR signaling can drive cells into senescence in the absence of DNA breaks

The ATR kinase is a key transducer of “replicative stress,” the type of genomic damage that has been postulated to be induced by oncogenes. Here we describe a cellular system in which we can unleash ATR activity at will, in the absence of any actual damage or additional signaling pathways triggered...

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Bibliographic Details
Main Authors: Toledo, Luis I., Murga, Matilde, Gutierrez-Martinez, Paula, Soria, Rebeca, Fernandez-Capetillo, Oscar
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2008
Subjects:
Research Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2216689/
https://ncbi.nlm.nih.gov/pubmed/18245444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.452308
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