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A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
Oncogene activation has been shown to generate replication-born DNA damage, also known as replicative stress (RS). Notably, the ATR kinase –and not ATM- is the primary responder to RS. One limitation for the study of ATR is the lack of potent inhibitors. We here describe a cell-based screening strat...
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| Publié dans: | Nat Struct Mol Biol |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4869831/ https://ncbi.nlm.nih.gov/pubmed/21552262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2076 |
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